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KMID : 0371320000590040458
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Journal of the Korean Surgical Society
2000 Volume.59 No. 4 p.458 ~ p.462
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Preliminary Result of Concurrent Chemotherapy and Radiotherapy in Stage I and II Breast Cancer Patients Treated with Breast Conservation Surgery
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황성보/Sung-Boo Hwang
한세환/서현숙/김성록/김홍용/Sehwan Han/Hyun-Suk Suh/Sung-Rok Kim/Hong-Yong Kim
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Abstract
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Purpose: Breast conserving surgery is increasingly performed in early stage breast cancer patients. A certain propotion of these patients are at substantial risk for systemic metastasis. However, there is no valid consensus about optimal
sequencing
of
chemotherapy and radiation therapy. Methods: We conducted a randomized prospective study to investigate whether concurrent chemotherapy and radiation therapy after breast conserving surgery are associated with increased toxicity. Fifty-seven
patients
with stage I or II breast cancer were randomly assigned to receive CMF chemotherpy either simultaneously with (n=37) or before (n=20) radiation therapy. Results: Moist desquamation was the most common adverse effect which occurred in 46% (16/37)
of
the
patients treated with concurrent chemotherapy and radiation therapy and 40% (8/20) of those treated with the sequential regimen. This difference between two groups was not statistically significant. Also the incidence of severe neutropenia
(WBC＜1,800)
or abnormal elevation of liver enzymes was not influenced by the sequencing of the adjuvant therapies. Arm edema was observed in 2 patients of the concurrent group and in 2 patients of the sequential regimen. Two patients treated with the
concurrent
regimen did not complete 6 cycles of chemotherapy while only one patient treated with sequential regimen did not. The incidence of toxicity during chemotherapy was not altered by the timing of radiation therapy. Conclusion: Chemotherapy and
radiation
therapy can be given concurrently after breast conserving surgery in stage I or II breast cancer patients without increase in serious toxicity.
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KEYWORD
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